YKL-5-124 TFA

Overview

YKL-5-124 TFA is a potent, selective, irreversible and covalent CDK7 inhibitor with IC 50 s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH , respectively. YKL-5-124 TFA is >100-fold greater selective for CDK7 than CDK9 and CDK2 , and inactive against CDK12 and CDK13 . YKL-5-124 TFA induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status.

Application

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Product Information

• Catalog No.: HY-101257B
• CAS No.: 2748220-93-9
• Molecular Formula: C30H34F3N7O5
• Molecular Weight: 629.63
• Purity: 99.74%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (3.97 mM); Clear solution
• Availability: In-stock

Source

Original product source