MK-212 (CPP) is an orally active, blood-brain barrier permeable agonist of 5-HT 1 C , 5-HT 2 and 5-HT 1 A receptors. MK-212 induces hyperthermia, nausea, arousal, irritability and restlessness, inhibits the elevation of plasma cortisol and prolactin , and reduces feelings of calmness and overall positive affect. MK-212 mediates anxiety-like behaviors and motor inhibition. MK-212 is applicable to research related to schizophrenia and anxiety disorders.
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