(R)-Niguldipine

Overview

(R)-Niguldipine, a R-epimer of Niguldipine ( HY-101390B ), is a calcium channel antagonist. (R)-Niguldipine exerts a vasodilatory effect by blocking calcium channels and reducing the transmembrane influx of calcium ions. (R)-Niguldipine can inhibit U-46619 ( HY-108566 )-induced coronary artery contraction in guinea pig Langendorff hearts ( pID 50 of 9.93), has high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes ( K i of 8.10), and lowers blood pressure in spontaneously hypertensive rats ( pED 30 of 5.55). (R)-Niguldipine can improve cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias.

Application

Products | Products > Disease Areas > Arrhythmias | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Heart Disease | Products > Disease Areas > Hypertension | Products > Disease Areas > Angina | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Calcium Channel

Product Information

• Catalog No.: HY-101390D
• CAS No.: 120054-86-6
• Molecular Formula: C36H39N3O6
• Molecular Weight: 609.71
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source