NCT-503

Overview

NCT-503 is a blood-brain barrier-permeable, non-competitive PHGDH inhibitor with an IC 50 of 2.5 μM against human PHGDH. NCT-503 reduces glucose-derived serine production and the incorporation of one-carbon units into nucleotides without decreasing PHGDH protein expression. NCT-503 prevents high selenium-induced insulin resistance in mice by regulating blood glucose and insulin levels and improving glucose tolerance, and also inhibits the growth of tumors overexpressing PHGDH . NCT-503 can be used in research related to insulin resistance and breast cancer .

Application

Products | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Phosphoglycerate Dehydrogenase (PHGDH)

Product Information

• Catalog No.: HY-101966
• CAS No.: 1916571-90-8
• Molecular Formula: C20H23F3N4S
• Molecular Weight: 408.48
• Purity: 99.69%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: 2.5 mg/mL (6.12 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source