RG3039 hydrochloride

Overview

RG3039 hydrochloride is an orally active, blood-brain barrier-permeable DcpS inhibitor with an IC 50 of 4.2 nM against hDcpS. RG3039 hydrochloride inhibits the decapping activity of DcpS and maintains DcpS in a catalytically inactive conformation in the central nervous system and other tissues. RG3039 hydrochloride extends survival and improves function in spinal muscular atrophy mice. RG3039 hydrochloride is applicable to research related to spinal muscular atrophy.

Application

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Product Information

• Catalog No.: HY-102020A
• CAS No.: 1466525-84-7
• Molecular Formula: C21H25Cl4N5O
• Molecular Weight: 505.27
• Purity: 98.15%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Availability: In-stock

Source

Original product source