KDOAM-25 citrate

Overview

KDOAM-25 citrate is a potent and highly selective histone lysine demethylases 5 ( KDM5 ) inhibitor with IC 50 s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 citrate increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Histone Demethylase

Product Information

• Catalog No.: HY-102047B
• CAS No.: 2448475-08-7
• Molecular Formula: C21H33N5O9
• Molecular Weight: 499.51
• Purity: 98.56%
• Storage: 4°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: ≥ 5 mg/mL (10.01 mM); Clear solution
• Availability: In-stock

Source

Original product source