Midostaurin

Overview

Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ , Syk , Flk-1 , Akt , PKA , c-Kit , c-Fgr , c-Src , FLT3 , PDFRβ and VEGFR1/2 with IC 50 s ranging from 22-500 nM. Midostaurin also upregulates endothelial nitric oxide synthase ( eNOS ) gene expression. Midostaurin shows powerful anticancer effects.

Application

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Product Information

• Catalog No.: HY-10230
• CAS No.: 120685-11-2
• Molecular Formula: C35H30N4O4
• Molecular Weight: 570.64
• Purity: 99.81%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: 5 mg/mL (8.76 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source