Adezmapimod hydrochloride

Overview

Adezmapimod (SB 203580; RWJ 64809) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC 50 s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 , respectively. Adezmapimod hydrochloride inhibits LCK , GSK3β and PKBα with IC 50 s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod hydrochloride does not disrupt JNK activity and is an autophagy and mitophagy activator.

Application

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Product Information

• Catalog No.: HY-10256A
• CAS No.: 869185-85-3
• Molecular Formula: C21H17ClFN3OS
• Molecular Weight: 413.90
• Purity: 99.37%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (6.04 mM); Clear solution
• Availability: In-stock

Source

Original product source