(-)-Enitociclib

Overview

(-)-Enitociclib ((R)-Enitociclib) is an enantiomer of Enitociclib (HY-103019E) with an optical rotation of (-). Enitociclib is a selective CDK9 inhibitor and apoptosis inducer . Enitociclib inhibits CDK9 activity and reduces the phosphorylation of Ser2 in the carboxyl-terminal domain (CTD) of RNA polymerase Pol II , thereby downregulating the transcription of key oncogenes such as MYC and MCL1 . Enitociclib has anti-proliferative activity targeting MYC + lymphoma and multiple myeloma (MM) cells, and has synergistic effects with Bortezomib ( HY-10227 ) and Lenalidomide ( HY-A0003 ), and can be used in the research of hematological malignancies.

Application

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Product Information

• Catalog No.: HY-103019B
• CAS No.: 1610408-96-2
• Molecular Formula: C19H18F2N4O2S
• Molecular Weight: 404.43
• Purity: 99.85%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.2 mg/mL (5.44 mM); Clear solution
• Availability: In-stock

Source

Original product source