EMD386088 is a potent and selective 5-HT6 receptor (5-HT6R) agonist with an EC 50 of 1.0 nM. EMD-386088 is inactive against other HT receptors except 5-HT3R (IC 50 of 34 nM). EMD386088 regulates the activity of ERK1/2. EMD386088 has the potential for the research of alzheimer's disease (AD) and schizophrenia.
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