CL-387785

Overview

CL-387785 (EKI-785; WAY-EKI 785) is an orally active EGFR inhibitor with an IC 50 of 370 pM. CL-387785 inhibits EGF-stimulated EGFR autophosphorylation with an IC 50 of approximately 5 nM. CL-387,785 exerts selective inhibition on cell lines overexpressing EGFR or c-erbB-2, whereas it shows weak inhibitory effects on cell lines with low expression of these two receptors. CL-387785 effectively induces cell cycle arrest and apoptosis . CL-387785 can be used for the research of non-small cell lung cancer and autosomal recessive polycystic kidney disease.

Application

Products | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Renal Disease | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Disease Areas > Polycystic Kidney Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Urogenital Disease | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Endocrinology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > EGFR | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-10325
• CAS No.: 194423-06-8
• Molecular Formula: C18H13BrN4O
• Molecular Weight: 381.23
• Purity: 99.31%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (6.56 mM); Clear solution
• Availability: In-stock

Source

Original product source