ML221

ML221
  • CAS No.:877636-42-5
  • Grade:98.45%
  • Formula:C17H11N3O6S
  • M.W.:385.35
  • Solvent:≥ 2 mg/mL (5.19 mM); Clear solution

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

Overview

ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC 50 s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC 80 of 10 nM in both assays.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Arrestin | Products > Signaling Pathways > Apelin Receptor (APJ)

Product Information

  • Catalog No.: HY-103254
  • CAS No.: 877636-42-5
  • Molecular Formula: C17H11N3O6S
  • Molecular Weight: 385.35
  • Purity: 98.45%
  • Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
  • Solubility: ≥ 2 mg/mL (5.19 mM); Clear solution
  • Availability: In-stock

Source

Original product source


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