CHM-1, a microtubule-destabilizing agent, inhibits tubulin polymerization . CHM-1 is a potent and selective antimitotic antitumor activity against human hepatocellular carcinoma. CHM-1 induces growth inhibition and apoptosis via G 2 -M phase arrest in human hepatocellular carcinoma cells by activation of Cdc2 kinase activity.
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