ML218

Overview

ML218 is a potent, selective and orally active T-type Ca 2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC 50 s of 310 nM and 270 nM for Cav3.2 and Cav3.3 , respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, K ATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier.

Application

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Product Information

• Catalog No.: HY-103309
• CAS No.: 1346233-68-8
• Molecular Formula: C19H26Cl2N2O
• Molecular Weight: 369.33
• Purity: 99.49%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 6.25 mg/mL (16.92 mM); Clear solution
• Availability: In-stock

Source

Original product source