JTE-907

Overview

JTE-907 is a selective and orally active cannabinoid CB2 receptor inverse agonist and exerts anti-inflammatory effects. JTE-907 upregulates IL-6 , MCP-1 , I L-1β , VEGF , ANGPTL4 , and TRPV1 in mature adipocytes. JTE-907 downregulates CB1 , MCP-1 , and IL-1β in preadipocytes. JTE-907 inhibits ear swelling in mice. JTE-907 reverses the protective effects of CB2 agonists and Anandamide ( HY-10863 ) against cytokine-evoked colonic mucosal damage. JTE-907 can be used for the research of allergic dermatitis, obesity, and colitis.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Skin Inflammation | Products > Disease Areas > Colitis | Products > Disease Areas > Obesity | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > ANGPTL | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > Cannabinoid Receptor | Products > Signaling Pathways > TRP Channel

Product Information

• Catalog No.: HY-103325
• CAS No.: 282089-49-0
• Molecular Formula: C24H26N2O6
• Molecular Weight: 438.47
• Purity: 98.54%
• Storage: 4°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Availability: In-stock

Source

Original product source