AM1172 is metabolically stable anandamide uptake inhibitor. AM1172 inhibits [ 3 H] anandamide transport in rat cortical neurons and human CCF-STTG1 astrocytoma cells with IC 50 values of 2.1 μM and 2.5 μM, respectively. AM1172 can significantly inhibit AEA hydrolysis and concurrently decrease AEA uptake. AM1172 can be used for the study of endocannabinoid system regulation.
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