DCPIB

Overview

DCPIB is a selective, reversible and potent inhibitor of volume-regulated anion channels ( VRAC ). DCPIB voltage-dependently activates potassium channels TREK1 and TRAAK , and inhibits TRESK , TASK1 and TASK3 ( IC 50 s: 0.14, 0.95, 50.72 μM, respectively). DCPIB is also a selective blocker of swelling-induced chloride current ( I Cl,swell ), with an IC 50 of 4.1 μM. DCPIB is a useful tool for investigating structure-function studies of K2P channels.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Chloride Channel | Products > Signaling Pathways > Potassium Channel

Product Information

• Catalog No.: HY-103371
• CAS No.: 82749-70-0
• Molecular Formula: C22H28Cl2O4
• Molecular Weight: 427.36
• Purity: 99.89%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.08 mg/mL (4.87 mM); Clear solution
• Availability: In-stock

Source

Original product source