SKF-83566 hydrobromide

Overview

SKF-83566 hydrobromide is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT 2 receptor ( K i =11 nM). SKF-83566 is a competitive DAT ( dopamine transporter ) inhibitor with an IC 50 of 5.7 μM. SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC 2 ) over AC 1 and AC 5 in the isolated rabbit thoracic aorta. SKF-83566 can be used for the research of parkinson’s disease and nicotine craving alleviation.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Dopamine Receptor | Products > Signaling Pathways > 5-HT Receptor | Products > Signaling Pathways > Adenylate Cyclase

Product Information

• Catalog No.: HY-103430
• CAS No.: 108179-91-5
• Molecular Formula: C17H19Br2NO
• Molecular Weight: 413.15
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source