Bicuculline methiodide

Overview

Bicuculline methiodide ((-)-Bicuculline methiodide) is a potent GABA A blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca 2+ -activated K + channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca 2+ -activated K + current.

Application

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Product Information

• Catalog No.: HY-103474
• CAS No.: 40709-69-1
• Molecular Formula: C21H20INO6
• Molecular Weight: 509.29
• Purity: 99.93%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 2.5 mg/mL (4.91 mM); Clear solution
• Availability: In-stock

Source

Original product source