(S)-SNAP5114

Overview

(S)-SNAP5114 is a non-covalent murine GABA transporter inhibitor with blood-brain barrier penetration ability, which exhibits significant subtype-selective inhibitory activity against mGAT4 (pIC 50 =5.71, pK i =4.56), much higher than its effects on mGAT1 , mGAT2 and mGAT3 . (S)-SNAP5114 elevates extracellular GABA concentrations by blocking the GABA reuptake mechanism, thereby enhancing thalamus-specific GABAergic signaling and exerting potential neuromodulatory effects. (S)-SNAP5114 is widely used in studies related to epilepsy, neuropathic pain, anxiety and depression, and various neurodegenerative diseases.

Application

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Product Information

• Catalog No.: HY-103504
• CAS No.: 157604-55-2
• Molecular Formula: C30H35NO6
• Molecular Weight: 505.60
• Purity: 98.09%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 5 mg/mL (9.89 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source