YM-202074 fumarate

Overview

YM-202074 fumarate is a selective, allosteric metabotropic glutamate receptor type 1 ( mGluR1 ) antagonist with high affinity. YM-202074 fumarate binds to the allosteric site of rat mGluR1 with a K i of 4.8 nM. YM-202074 fumarate also inhibits mGluR1 -mediated inositol phosphate production in rat cerebellar granule cells with an IC 50 of 8.6 nM. YM-202074 fumarate has potent neuroprotective effects in transient MCA (tMCA) occlusion rat models.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > mGluR

Product Information

• Catalog No.: HY-103556
• CAS No.: 299900-84-8
• Molecular Formula: C56H72N8O16S2
• Molecular Weight: 1177.34
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source