LY456236 free base

Overview

LY456236 free base is a selective, non-competitive and orally active antagonist of glutamate receptor 1 ( mGlu1 ), which can inhibit phosphatidylinositol hydrolysis with an IC 50 of 0.145 μM. LY456236 free base can also inhibit EGFR , with an IC 50 of 0.918 μM. LY456236 free base blocks cell proliferation by inhibiting the MAPK pathway, reversing the anti- apoptotic effect of DHPG ( HY-12598A ). LY456236 free base can be used in epilepsy research.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Epilepsy | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > mGluR | Products > Signaling Pathways > EGFR

Product Information

• Catalog No.: HY-103566A
• CAS No.: 338738-57-1
• Molecular Formula: C16H15N3O2
• Molecular Weight: 281.31
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source