MK-2206 dihydrochloride

Overview

MK-2206 dihydrochloride (MK-2206 2HCl) is an orally active pan-AKT inhibitor, with IC 50 values of 8 nM, 12 nM and 65 nM against AKT1 , AKT2 and AKT3 , respectively. MK-2206 dihydrochloride inhibits the Akt / mTOR signaling pathway and reduces the levels of downstream GSK3β and Mcl-1 via proteasomal degradation. MK-2206 dihydrochloride induces G1-phase cell cycle arrest, apoptosis , epithelial-mesenchymal transition, fibroblast activation and extracellular matrix deposition. MK-2206 dihydrochloride causes transient hyperglycemia and hyperinsulinemia in animals . MK-2206 dihydrochloride can be used in research related to solid tumors, renal fibrosis and hypercholesterolemia.

Application

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Product Information

• Catalog No.: HY-10358
• CAS No.: 1032350-13-2
• Molecular Formula: C25H23Cl2N5O
• Molecular Weight: 480.39
• Purity: 99.94%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 1.67 mg/mL (3.48 mM); Clear solution
• Availability: In-stock

Source

Original product source