MKC8866

Overview

MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC 50 of 0.29 μM in human vitro. MKC8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC 50 of 0.52 μM and unstresses RPMI 8226 cells with an IC 50 of 0.14 μM. MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibits prostate cancer (PCa) tumor growth.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Prostate Cancer | Products > Disease Areas > Urogenital Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > IRE1

Product Information

• Catalog No.: HY-104040
• CAS No.: 1338934-59-0
• Molecular Formula: C18H19NO7
• Molecular Weight: 361.35
• Purity: 99.95%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 20 mg/mL (55.35 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source