Fedratinib hydrochloride hydrate

Overview

Fedratinib hydrochloride hydrate (TG-101348 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC 50 s of 3 nM for both JAK2 and JAK2V617F kinase . Fedratinib hydrochloride hydrate shows 35- and 334-fold selectivity over JAK1 and JAK3 , respectively. Fedratinib hydrochloride hydrate induces cancer cell apoptosis and has the potential for myeloproliferative disorders research.

Application

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Product Information

• Catalog No.: HY-10409A
• CAS No.: 1374744-69-0
• Molecular Formula: C27H40Cl2N6O4S
• Molecular Weight: 615.62
• Purity: 99.92%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (4.06 mM); Clear solution
• Availability: In-stock

Source

Original product source