BIX-01294

Overview

BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC 50 s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy . BIX-01294 has antitumor activity in recurrent tumor cells.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Autophagy | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Histone Methyltransferase | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-10587
• CAS No.: 935693-62-2
• Molecular Formula: C28H38N6O2
• Molecular Weight: 490.64
• Purity: 98.44%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.75 mg/mL (5.60 mM); Clear solution
• Availability: In-stock

Source

Original product source