AVN-211 (CD-008-0173) is a selective and orally active 5HT 6 R antagonist with an IC 50 of 2.34 nM and a K i of 1.09 nM. AVN-211 exhibits 5K-fold higher 5HT 6 R selectivity over other 65 receptors, enzymes , and ion channels. AVN-211 significantly improves cognitive and anxiety behaviors in various AD animal models, and has good safety profiles. AVN-211 can be used for the study of Alzheimer's dementia.
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > 5-HT Receptor
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