Urotensin-II receptor antagonist-1

Overview

Urotensin-II receptor antagonist-1 (compound 1) is a low oral bioavailability (F=0-3%, rat) selective human Urotensin II receptor antagonist, K i =16 nM (test on HEK293 cells expressing recombinant human UT receptor). Urotensin-II receptor antagonist-1 inhibits cytochrome P450 ( IC 50 =0.75 μM, CYP2D6 ; 1.4 μM, CYP3A4 ), inhibits κ-opioid receptor ( EC 50 =3.2 μM), targets cardiac sodium channels (K i =2.5 μM).

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Urotensin Receptor | Products > Signaling Pathways > Opioid Receptor | Products > Signaling Pathways > Sodium Channel | Products > Signaling Pathways > Cytochrome P450

Product Information

• Catalog No.: HY-10672
• CAS No.: 1034708-07-0
• Molecular Formula: C25H31Cl2N3O
• Molecular Weight: 460.44
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source