Asoxime dichloride (HI-6) is an orally active thiosemicarbazone-based antidote. Asoxime dichloride is a reversible inhibitor of AChE , and its core mechanism of action is to re-activate AChE inhibited by nerve toxins, thereby restoring the cholinergic nerve function. Asoxime dichloride significantly restores the function of poisoned muscles without reactivating AChE . Asoxime dichloride is an antagonist of acetylcholine receptors ( AChRs ), including nicotinic receptor and α7 nAChR . Asoxime dichloride can serve as an effective immunomodulator, improving the immune effect of the nervous system.
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