JNJ-10229570

JNJ-10229570
  • CAS No.:524923-88-4
  • Grade:98.0%
  • Formula:C22H19N3O2S
  • M.W.:389.47
  • Solvent:≥ 2.08 mg/mL (5.34 mM); Clear solution

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

Overview

JNJ-10229570 is an antagonist of melanocortin receptor 1 ( MC1R ) and melanocortin receptor 5 ( MC5R ) , which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125 I-NDP-α-MSH to cells expressing human MC1R and MC5R , with IC 50 values of 270 nM and 200 nM, respectively.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Endocrinology | Products > Signaling Pathways > Melanocortin Receptor

Product Information

  • Catalog No.: HY-107139
  • CAS No.: 524923-88-4
  • Molecular Formula: C22H19N3O2S
  • Molecular Weight: 389.47
  • Purity: 98.0%
  • Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
  • Solubility: ≥ 2.08 mg/mL (5.34 mM); Clear solution
  • Availability: In-stock

Source

Original product source


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