AX-024 hydrochloride

Overview

AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC 50 ~1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6 , TNF-α , IFN-γ , IL-10 and IL-17A .

Application

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Product Information

• Catalog No.: HY-107390A
• CAS No.: 1704801-24-0
• Molecular Formula: C21H23ClFNO2
• Molecular Weight: 375.86
• Purity: 99.23%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (6.65 mM); Clear solution
• Availability: In-stock

Source

Original product source