YM-230888

Overview

YM-230888 is an orally active, selective and allosteric mGlu1 receptor antagonist with a K i of 13 nM. YM-230888 inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells with an IC 50 of 13 nM. YM-230888 shows antinociceptive response in Streptozotocin ( HY-13753 )-induced hyperalgesia models. YM-230888 significantly reduces pain parameters in complete Freund's adjuvant ( HY-153808 )-induced arthritic pain models.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > mGluR

Product Information

• Catalog No.: HY-107510
• CAS No.: 446257-23-4
• Molecular Formula: C19H28N4OS
• Molecular Weight: 360.52
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source