YM-244769 hydrochloride

Overview

YM-244769 hydrochloride is a potent, selective and orally active Na + /Ca 2+ exchanger ( NCX ) inhibitor. YM-244769 hydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current ( Ca 2+ entry mode), with IC 50 s of 18 nM and 50 nM, respectively. YM-244769 hydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 hydrochloride can also increase urine volume and urinary excretion of electrolytes in mice.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Cardiovascular Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Neurological Disease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Na+/Ca2+ Exchanger

Product Information

• Catalog No.: HY-107659
• CAS No.: 837424-39-2
• Molecular Formula: C26H23ClFN3O3
• Molecular Weight: 479.93
• Purity: 98.09%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source