Guggulsterone

Overview

Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii . Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products ( IAP1, xIAP , Bfl-1/A1, Bcl-2 , cFLIP and survivin ), modulation of cell cycle proteins ( cyclin D1 and c-Myc ), activation of caspases and JNK , inhibition of Akt . Guggulsterone, a farnesoid X receptor ( FXR ) antagonist, with IC 50 s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone ( HY-N7781 ) and (Z)-Guggulsterone ( HY-110066 ), respectively.

Application

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Product Information

• Catalog No.: HY-107738
• CAS No.: 95975-55-6
• Molecular Formula: C21H28O2
• Molecular Weight: 312.45
• Purity: 99.78%
• Storage: 4°C, protect from light * In solvent : -80°C, 2 years; -20°C, 1 year (protect from light)
• Solubility: 1.25 mg/mL (4.00 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source