BI-882370

Overview

BI-882370 is a potent and selective RAF kinase inhibitor that binds to the ATP binding site of the kinase positioned in the DFG-out (inactive) conformation of the BRAF kinase. BI-882370 (BI 882370) inhibits the oncogenic BRAF V600E -mutant, the WT BRAF and CRAF kinases with IC 50 s of 0.4, 0.8, and 0.6 nM, respectively. BI-882370 also inhibits SRC family kinases.

Application

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Product Information

• Catalog No.: HY-107779
• CAS No.: 1392429-79-6
• Molecular Formula: C28H33F2N7O2S
• Molecular Weight: 569.67
• Purity: 98.55%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 1.79 mg/mL (3.14 mM); Clear solution
• Availability: In-stock

Source

Original product source