MI-2-2

Overview

MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (K d =22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation.

Application

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Product Information

• Catalog No.: HY-108350
• CAS No.: 1454920-20-7
• Molecular Formula: C17H20F3N5S2
• Molecular Weight: 415.50
• Purity: 99.94%
• Storage: -20°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 3.75 mg/mL (9.03 mM); Clear solution
• Availability: In-stock

Source

Original product source