Alsterpaullone

Overview

Alsterpaullone (9-Nitropaullone) is a potent CDK inhibitor, with IC 50 s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B , CDK2/cyclin A , CDK2/cyclin E and CDK5/p35 , respectively. Alsterpaullone also competes with ATP for binding to GSK-3alpha/GSK-3beta with IC 50 s of both 4 nM. Alsterpaullone has antitumor activity, and possesses potential for the study in neurodegenerative and proliferative disorders. Alsterpaullone induces apoptosis in leukemia cell line.

Application

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Product Information

• Catalog No.: HY-108359
• CAS No.: 237430-03-4
• Molecular Formula: C16H11N3O3
• Molecular Weight: 293.28
• Purity: 99.85%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Availability: In-stock

Source

Original product source