INDY

Overview

INDY is a potent and ATP-competitive Dyrk1A and Dyrk1B inhibitor with IC 50 s of 0.24 μM and 0.23 μM, respectively. INDY binds in the ATP pocket of the enzyme and has a K i value of 0.18 μM for Dyrk1A. INDY sharply reduces the self-renewal capacity of normal and tumorigenic cells in primary Glioblastoma (GBM) cell lines and neural progenitor cells.

Application

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Product Information

• Catalog No.: HY-108476
• CAS No.: 1169755-45-6
• Molecular Formula: C12H13NO2S
• Molecular Weight: 235.30
• Purity: 99.32%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (10.62 mM); Clear solution
• Availability: In-stock

Source

Original product source