JNK-9L

CAS No.：1128096-64-9
Grade：98.06%
Formula：C26H27FN8O2
M.W.：502.54
Solvent：≥ 1 mg/mL (1.99 mM); Clear solution

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

JNK-9L (Compound 9l) is a BBB-penetrable and ATP-competitive JNK inhibitor with IC 50 s of 0.099 and 0.148 μM for JNK1 and JNK3 , respectively. JNK-9L significantly inhibits c-jun phosphorylation and Streptozotocin ( HY-13753 )-induced ROS generation with an IC 50 of 0.8 nM. JNK-9L can be used for neurodegenerative disorders like Parkinson’s disease research .

Application

Products | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Depression | Products > Disease Areas > Pain | Products > Disease Areas > Parkinson's Disease | Products > Disease Areas > Obesity | Products > Disease Areas > Lung Fibrosis | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > JNK | Products > Signaling Pathways > Reactive Oxygen Species (ROS)

Product Information

Catalog No.: HY-10851
CAS No.: 1128096-64-9
Molecular Formula: C26H27FN8O2
Molecular Weight: 502.54
Purity: 98.06%
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Solubility: ≥ 1 mg/mL (1.99 mM); Clear solution
Availability: In-stock

Source

Original product source

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