UCL 1684 (dibromide) is a first nanomolar, non-peptidic small conductance calcium-activated potassium ( SK ) channel blocker. UCL 1684 (dibromide) is effective in preventing the development of atrial fibrillation due to potent atrial-selective inhibition of I Na . UCL 1684 (dibromide) causes atrial-selective prolongation of ERP secondary to induction of postrepolarization refractoriness.
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