LY2183240

Overview

LY2183240 is a highly potent blocker of anandamide uptake ( IC 50 = 270 pM; K i =540 nM). LY2183240 is a potent, covalent inhibitor of the endocannabinoid-degrading enzyme fatty acid amide hydrolase ( FAAH ) with an IC 50 of 12.4 nM. LY2183240 inactivates FAAH by carbamylation of the enzyme's serine nucleophile. LY2183240 also inhibits several other brain serine hydrolases with IC 50 s of 5.3, 0.09, 8.2 nM for MAG lipase , bh6 and KIAA1363, respectively .

Application

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Product Information

• Catalog No.: HY-10865
• CAS No.: 874902-19-9
• Molecular Formula: C17H17N5O
• Molecular Weight: 307.35
• Purity: 98.00%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (8.13 mM); Clear solution
• Availability: In-stock

Source

Original product source