LY2183240

CAS No.：874902-19-9
Grade：98.00%
Formula：C17H17N5O
M.W.：307.35
Solvent：≥ 2.5 mg/mL (8.13 mM); Clear solution

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

LY2183240 is a highly potent blocker of anandamide uptake ( IC 50 = 270 pM; K i =540 nM). LY2183240 is a potent, covalent inhibitor of the endocannabinoid-degrading enzyme fatty acid amide hydrolase ( FAAH ) with an IC 50 of 12.4 nM. LY2183240 inactivates FAAH by carbamylation of the enzyme's serine nucleophile. LY2183240 also inhibits several other brain serine hydrolases with IC 50 s of 5.3, 0.09, 8.2 nM for MAG lipase , bh6 and KIAA1363, respectively .

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Pain | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Autophagy | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > FAAH | Products > Signaling Pathways > Autophagy

Product Information

Catalog No.: HY-10865
CAS No.: 874902-19-9
Molecular Formula: C17H17N5O
Molecular Weight: 307.35
Purity: 98.00%
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
Solubility: ≥ 2.5 mg/mL (8.13 mM); Clear solution
Availability: In-stock

Source

Original product source

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