Padsevonil (UCB0942) is a potent antiepileptic agent that selectively acts on presynaptic and postsynaptic targets. Padsevonil binds to synaptic vesicular protein 2 ( SV2 ) with high affinity. Padsevonil is also a positive allosteric modulator and partial agonist of GABA A R , with high potency against α1 and α5 receptors. Padsevonil has antiepileptic effects in a variety of rodent models.
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