Masupirdine free base (SUVN-502 free base) is a potent, selective, orally active, and brain-penetrating 5-HT 6 receptor antagonist ( K i of 2.04 nM for human 5-HT 6 receptor). Masupirdine free base has pro-cognitive effects on all stages of cognition (acquisition, consolidation, and retention), and can reverse Scopolamine (HY-N0296), MK-801 ( HY-15084B )-induced and aging-related memory deficits. Masupirdine free base can be used in the research of Alzheimer's disease.
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > 5-HT Receptor
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