Masupirdine mesylate (SUVN-502 mesylate) is a potent, selective, orally active, and brain-penetrating 5-HT 6 receptor antagonist ( K i of 2.04 nM for human 5-HT 6 receptor). Masupirdine mesylate has pro-cognitive effects on all stages of cognition (acquisition, consolidation, and retention), and can reverse Scopolamine (HY-N0296), MK-801 ( HY-15084B )-induced and aging-related memory deficits. Masupirdine mesylate can be used in the research of Alzheimer's disease.
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