UNC0224

Overview

UNC0224 is a potent and selective histone methyltransferase G9a inhibitor with a K i of 2.6 nM, an IC 50 of 15 nM and a K d of 23 nM. UNC0224 also potently inhibits b>GLP with assay-dependent IC 50 values of 20-58 nM. UNC0224 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Histone Methyltransferase

Product Information

• Catalog No.: HY-10929
• CAS No.: 1197196-48-7
• Molecular Formula: C26H43N7O2
• Molecular Weight: 485.67
• Purity: 98.93%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 1.67 mg/mL (3.44 mM); Clear solution
• Availability: In-stock

Source

Original product source