Amonafide dihydrochloride

Overview

Amonafide dihydrochloride (AS1413 dihydrochloride) is a topoisomerase II ( Topo II ) inhibitor and DNA intercalator with activity in inducing apoptotic signaling. Amonafide dihydrochloride can inhibit the binding of Topo II to DNA, thereby preventing the synthesis of DNA and RNA. Amonafide dihydrochloride maintains cytotoxic activity in the presence of P-glycoprotein-mediated multidrug resistance (MDR).

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Others | Products > Signaling Pathways > Topoisomerase

Product Information

• Catalog No.: HY-10982A
• CAS No.: 150091-68-2
• Molecular Formula: C16H19Cl2N3O2
• Molecular Weight: 356.25
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source