KHS101 is a blood-brain barrier-penetrant anticancer agent that primarily functions by inhibiting HSPD1 ( IC 50 = 14.4 μM) and TACC3 across different cellular backgrounds. KHS101 promotes the aggregation of HSPD1 with client proteins, destabilizes TACC3 , and reduces the levels of TACC3 , Aurora A and PLK1 . KHS101 induces autophagy , apoptosis , cell cycle exit and neuronal differentiation; it suppresses cancer cell growth, motility, EMT and stemness; it also impairs mitochondrial bioenergetics and glycolysis in glioblastoma cells. KHS101 can be used in research related to glioblastoma multiforme and breast cancer .
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