GW405833 hydrochloride

Overview

GW405833 (L768242) hydrochloride is a potent, selective cannabinoid receptor 2 ( CB 2 ) agonist. GW405833 has EC 50 and K i values ​​of 0.65 nM and 3.92 nM for CB 2 , and EC 50 and K i values ​​of 16.1 μM and 4772 nM for CB 1 . GW405833 hydrochloride also exhibits non-competitive CB 1 antagonist, exerting its analgesic effect through a CB 1 receptor (rather than CB 2 ) dependent mechanism. GW405833 hydrochloride can significantly inhibit the production of cAMP stimulated by Forskolin ( HY-15371 ). GW405833 hydrochloride inhibits glycolysis by down-regulating HIF-1α , thereby alleviating acute liver failure (ALF).

Application

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Product Information

• Catalog No.: HY-110036A
• CAS No.: 1202865-22-2
• Molecular Formula: C23H25Cl3N2O3
• Molecular Weight: 483.82
• Purity: 99.59%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source