TRPV1 antagonist 9

Overview

TRPV1 antagonist 9 (compound 13c) is an orally active transient receptor potential vanilloid 1 ( TRPV1 ) channel antagonist. TRPV1 antagonist 9 blocks Ca 2+ uptake by CHO cells expressing TRPV1 receptors with IC 50 values are 0.6 and 0.8 nM for Capsaicin ( HY-10448 ) and acid-induced Ca 2+ uptake, respectively. TRPV1 antagonist 9 blocks Capsaicin ( HY-10448 )-induced flinch response and causes hyperthermia in rats.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > TRP Channel

Product Information

• Catalog No.: HY-110091
• CAS No.: 939040-79-6
• Molecular Formula: C22H19F3N6O3
• Molecular Weight: 472.42
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source