JTE-607

Overview

JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including TNF-α , IL-1β , IL-6 , IL-8 and IL-10 , from LPS-stimulated human PBMCs, with IC 50 s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607.

Application

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Product Information

• Catalog No.: HY-110133
• CAS No.: 188791-09-5
• Molecular Formula: C25H33Cl4N3O5
• Molecular Weight: 597.36
• Purity: 98.64%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.08 mg/mL (3.48 mM); Clear solution
• Availability: In-stock

Source

Original product source